Publications
Pre-prints
Peer reviewed publications
[15] Matthews, E.R., Johnson, O.D., Horn, K.J., Gutierrez J.A., Powell, S.R., Ward, M.C#. Anthracyclines induce cardiotoxicity through a shared gene expression response signature. PLOS Genetics doi.org/10.1371/journal.pgen.1011164 (2024). [Link]
[14] Findley, A.S., Monziani, A., Richards, A.L., Rhodes, K., Ward, M.C., Kalita, C.A., Alazizi, A., Pazokitoroudi, A., Sankararaman, S., Wen, X., Lanfear, D.E., Pique-Regi, R. Gilad, Y., Luca, F. Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. eLife doi.org/10.7554/eLife.67077 (2021). [Link]
[13] Ward, M.C.*#, Banovich, N.E.*, Sarkar, A., Stephens, M. and Gilad, Y.#. Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes. eLife doi.org/10.7554/eLife.57345 (2021). [Link]
* Co-first authors
# Co-corresponding authors
[12] D’Antonio-Chronowska, A., Donovan, M.K.R., Benaglio, P., Greenwald, W.W., Ward, M.C., Matsui, H., Fujita, K., Hashem, S., Soncin, F., Parast, M., Adler, E., Smith, E.N., D’Antonio, M. and Frazer, K.A. Human iPSC gene signatures and X chromosome dosage impact response to WNT inhibition and cardiac differentiation fate. Stem Cell Reports 13, 924-938 (2019). [Link]
[11] Ward, M.C.# and Gilad, Y.# A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. eLife doi.org/10.7554/eLife.42374 (2019). [Link]
# Co-corresponding authors
Featured in eLife Insight article: Pollen, A., and Pavlovic, B.J. Stem Cells: Getting to the heart of cardiovascular evolution in humans. eLife doi.org/10.7554/eLife.47807 (2019). [Link]
[10] Ward, M.C.#, Zhao, S., Luo, K., Pavlovic, B.J., Karimi, M.M., Stephens, M. and Gilad, Y.# Silencing of transposable elements may not be a major driver of regulatory evolution in primate induced pluripotent stem cells. eLife doi.org/10.7554/eLife.33084 (2018). [Link]
# Co-corresponding authors
Teichmann, S. and Hagai, T.: F1000Prime Recommendation doi.org/10.3410/f.733031339.793546344 (2018). [Link]
[9] Banovich, N.E.*, Li, Y.I.*, Raj, A.*, Ward, M.C., Greenside, P., Calderon, D., Tung, P.Y., Burnett, J.E., Myrthil, M., Thomas, S.M., Burrows, C.K., Gallego Romero, I., Pavlovic, B.J., Kundaje, A., Pritchard, J.K. and Gilad, Y. Impact of regulatory variation across human iPSCs and differentiated cells. Genome Research 28, 122-131 (2018). [Link]
[8] Ward, M.C.# and Gilad, Y#. Human genomics: Cracking the regulatory code. Nature 550, 190-191 (2017). [Link]
# Co-corresponding authors
[7] Ernst, C., Pike J., Aitken, S.J., Long, H.K., Eling, N., Stojic, L., Ward, M.C., Connor, F., Rayner, T.F., Lukk, M., Klose, R.J., Kutter, C. and Odom, D.T. Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis. eLife doi.org/10.7554/eLife.20235 (2016). [Link]
[6] Gallego Romero, I.*, Pavlovic, B.J.*, Hernando-Herraez, I., Zhou, X., Ward, M.C., …, Gilad, Y. A Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics eLife doi.org/10.7554/eLife.07103 (2015). [Link]
[5] Carbone, L., Harris, A.R., Gnerre, S., Veeramah, K.R., Lorente-Galdos, B., Huddleston J., Meyer, T.J., Herrero J., Roos, C., Aken, B., …, Ward, M.C., …, Gibbs, R.A. The gibbon genome provides a novel perspective on the accelerated karyotype evolution of small apes. Nature 513, 195-201 (2014). [Link]
[4] Schwalie, P.C.*, Ward, M.C.*, Cain, C.E., Faure, A.J., Gilad, Y., Odom, D.T. and Flicek, P. Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primates. Genome Biology 14, R148 (2013). [Link]
* Co-first authors
[3] Ward, M.C.*, Wilson, M.D.*, Barbosa-Morais, N.L., Schmidt, D., Stark, R., Pan, Q., Schwalie, P.C., Menon, S., Lukk, M., Watt, S., Thybert, D., Kutter, C., Kirschner K., Flicek, P., Blencowe, B.J. and Odom, D.T. Latent regulatory potential of human-specific repetitive elements. Molecular Cell 49, 262-272 (2013). [Link]
* Co-first authors
[2] Scally, A., Dutheil, J.Y., Hillier, L.W., Jordan, G.E., Goodhead, I., Herrero, J., Holboth, A., Lappalainen, T., Mailund, T., Marques-Bonet, T., ... Ward, M.C., ..., Durbin, R. Insights into hominid evolution from the gorilla genome sequence. Nature 483, 169-175 (2012). [Link]
[1] Ward, M.C., van der Watt, P.J., Tzoneva, G. and Leaner, V.D. Deregulated LAP2α expression in cervical cancer associates with aberrant E2F and p53 activities. IUBMB Life 63, 1018-1026 (2011). [Link]